Department of Medical Oncology, and National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, CAMS Key Laboratory of Translational Research on Lung Cancer, State Key Laboratory of Molecular Oncology, Chinese Acade
4 developments in the corpus
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A theoretical framework proposing mechanistic explanations for neural scaling laws through representational geometry; lacks empirical validation, direct experimental test, or application to real systems.
Small single-center matched cohort study (31 per group) with retrospective design and surrogate endpoints; findings on concurrent nephropathy and renal function decline are clinically relevant but require validation in larger prospective studies.
This is a mechanistic study identifying PKM2 as a methionine sensor via chemoproteomic profiling and biochemical validation in cells, with therapeutic speculation but no clinical efficacy data or in vivo validation.
Large real-world pharmacovigilance study of 19,697 adverse event reports confirms known structure-toxicity relationships for ADCs, but lacks comparative efficacy data and uses observational methods without prospective controls.