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Yiqiang Zheng

Southern University of Science and Technology

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AUG 13, 2026 · JOURNAL ARTICLE

“Trojan”Methionine Probe Reveals PKM2as a Methionine-Sensing Protein in the mTORC1 Pathway

Journal of the American Chemical Society

This is a mechanistic study identifying PKM2 as a methionine sensor via chemoproteomic profiling and biochemical validation in cells, with therapeutic speculation but no clinical efficacy data or in vivo validation.

Hypothesis-GeneratingJie Wang Yiqiang Zheng Cang Wu

Study details

DesignMechanistic cell biology study with chemopr…

InterventionPhotoaffinity analogue of methionine for ca…

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