Retrospective cohort study of 330 patients reporting an obesity paradox in mHSPC; confirms known associations but BMI did not retain independent significance in multivariate analysis, limiting practice implications.
High-quality meta-analysis of 23 Phase II/III RCTs (n=8797) demonstrating clinically meaningful improvements in DFS, OS, and pCR with carboplatin-containing chemotherapy in TNBC, with rigorous pooling and quantified safety trade-offs.
A well-designed quasi-experimental study from a single tertiary centre showing clinically meaningful improvements in PPI prescribing appropriateness and cost reduction, but limited by lack of randomization and single-site geography.
A rigorous meta-analysis of four Phase III RCTs with mature survival data demonstrating clear efficacy separation between drug classes (abemaciclib/ribociclib benefit vs palbociclib non-benefit) in a large population, with adequate power and low heterogeneity.