Cell Death and Differentiation

OCT 23, 2026 · JOURNAL ARTICLE

HMGB1 directly activates BAP1 transcription to sustain tumor growth in mesothelioma

Cell Death and Differentiation

Abstract BAP1 and HMGB1 alterations are implicated in the pathogenesis of mesothelioma, an aggressive cancer of the membranes covering the thoracic and abdominal cavities. Genetic

AUG 11, 2026 · JOURNAL ARTICLE

Absence of EGFR signalling in granulocytic cells relieves immunosuppression sensitising CRC metastases to immune checkpoint therapy

Cell Death and Differentiation

Sound preclinical mechanistic study demonstrating that EGFR deletion in myeloid cells sensitizes CRC metastases to anti-PD-L1 immunotherapy, with supporting RNA-seq data and clinical survival association, but limited by syngeneic model and lack of human trial data.