AUG 11, 2026 · JOURNAL ARTICLE
Absence of EGFR signalling in granulocytic cells relieves immunosuppression sensitising CRC metastases to immune checkpoint therapy
Cell Death and Differentiation
Sound preclinical mechanistic study demonstrating that EGFR deletion in myeloid cells sensitizes CRC metastases to anti-PD-L1 immunotherapy, with supporting RNA-seq data and clinical survival association, but limited by syngeneic model and lack of human trial data.
Study details
DesignSyngeneic preclinical CRC liver metastasis…
InterventionEGFR deletion in myeloid cells; anti-PD-L1…
ComparatorWild-type or proficient myeloid EGFR; anti-…