Post-translational modifications (PTMs) of histone H3 at lysine 9 (H3K9) contribute to chromatin homeostasis and transcriptional regulation and have been implicated in cancer progr
Attenuated oncolytic bacteria represent a promising targeted delivery platform for cancer therapy; however, the lack of non-invasive biomarkers to monitor their persistent intra-tu
N⁴-acetylcytidine (ac⁴C) is an evolutionarily conserved RNA modification that was initially identified in transfer RNA (tRNA) and ribosomal RNA (rRNA). Increasing evidence has subs
CD133 (prominin-1) is among the most widely used cancer stem cell markers, yet two decades of research have yielded persistent contradictions: CD133-negative cells can be tumorigen
A narrative review synthesizing preclinical mechanistic evidence on VHL targets and proposing therapeutic modalities, lacking clinical trial data or human evidence to support practice recommendations.
Preclinical mechanistic study in transgenic mice and PDX models with a novel protein delivery approach; no clinical efficacy data or human trials reported, only mechanism validation and proof-of-concept in xenografts.