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Epigenetics and DNA Methylation / Chromatin Remodeling and Cancer · Journal article
Molecular Cancer · August 7, 2026
A consensus or society position rather than new primary data.
This is a narrative review integrating mechanistic knowledge of chromatin remodeling and 3D genome organization in cancer biology, proposing a hierarchical framework and surveying therapeutic strategies in development and clinical use. It is a synthesis of existing evidence and expert opinion rather than a report of new empirical findings, and does not provide outcome data to support specific clinical recommendations.
Narrative review. Cancer patients (general category); specific tumor types, stages, or patient demographics not detailed in abstract..
Chromatin remodelers are heavily mutated in cancer patients and represent a promising therapeutic target The review proposes a hierarchical framework distinguishing 'first-level' (classical) and 'higher-order' chromatin remodeling mechanisms Cohesin complex identified as a primary mediator of 3D genomic organization in cancer
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This review provides a conceptual framework and research agenda for clinicians and researchers evaluating chromatin-remodeling-targeted therapies. It does not present efficacy or safety data from clinical trials and should be read as a synthesis of current understanding and future directions rather than evidence for changing practice.
This is a comprehensive narrative review synthesizing mechanistic insights into chromatin remodeling in cancer and cataloging therapeutic strategies, without reporting original experimental data or clinical trial results.
As stated by the source record.
This review provides a conceptual framework and research agenda for clinicians and researchers evaluating chromatin-remodeling-targeted therapies. It does not present efficacy or safety data from clinical trials and should be read as a synthesis of current understanding and future directions rather than evidence for changing practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.
Abstract Chromatin remodeling comprises a set of molecular mechanisms that regulate gene transcription, DNA replication, and DNA repair by altering nucleosome structure. Previous studies have found that chromatin remodelers are heavily mutated in cancer patients, and targeting aberrant chromatin remodeling activities holds great potential for clinical benefit. Despite these promising findings, several significant hurdles remain before this strategy can be successfully transitioned from bench to bedside. The classic concept of chromatin remodeling focuses on the linear 2D chromatin structural level. While the emergence of sophisticated sequencing modalities has underscored the significance of 3D chromatin architecture, the mechanistic underpinnings and broader implications for cancer biology continue to be largely elusive. This review provides a comprehensive synthesis of the mechanisms and functional roles of classical chromatin remodelers within both physiological and neoplastic contexts. Furthermore, we integrate emerging insights regarding the cohesin complex as a primary mediator of three-dimensional (3D) genomic organization. By proposing a hierarchical framework that distinguishes between 'first-level' (classical) and 'higher-order' chromatin remodeling, we aim to provide a more holistic understanding of the integrated regulatory networks governing chromatin architecture. Furthermore, we have systematically cataloged the landscape of therapeutic strategies targeting chromatin remodelers in oncology. By evaluating the divergence between clinically approved therapies and those currently in developmental pipelines, we delineate the primary challenges confronting the field and propose strategic directions for future research. Collectively, we have delineated the multifaceted contributions of chromatin remodeling to cancer progression. The strategic modulation of these remodeling processes represents a vital frontier in the development of novel therapeutic interventions and is likely to emerge as a primary focus for future cancer management strategies.
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