Chromatin Remodeling and Cancer

SEP 8, 2026 · JOURNAL ARTICLE

Targeting LZK in Oral Squamous Cell Carcinoma: A Review of Local PROTAC Delivery via Dissolving Microneedles

Theoretical and Natural Science

This is a narrative review proposing a theoretical therapeutic strategy combining LZK-PROTAC degradation with dissolving microneedle delivery for OSCC; no clinical trial data, preclinical evidence, or mechanistic validation is presented.

SEP 4, 2026 · JOURNAL ARTICLE

Clinical outcomes of SMARCA4-deficient thoracic tumor patients and therapeutic value of immune checkpoint inhibitors in advanced stage patients

BMC Cancer

Single-centre retrospective cohort with small advanced-stage subgroups (n=16 per arm) and exploratory analyses; unadjusted PFS benefit for ICIs did not survive adjustment, and authors explicitly state findings are hypothesis-generating rather than confirmatory.

AUG 17, 2026 · JOURNAL ARTICLE

Immunotherapy plus chemotherapy improves survival in SMARCA4-deficient NSCLC: a real-world cohort study

Frontiers in Immunology

Small single-center retrospective cohort (n=22) with univariate analysis only, addressing a rare disease with no established standard, yielding a promising survival signal but explicitly requiring large prospective validation.

AUG 14, 2026 · JOURNAL ARTICLE

Structural plasticity, selective ligandability, and the challenge of functional redundancy in TIF1 bromodomain mediated tumorigenesis

Discover Oncology

A narrative review article proposing a research roadmap and therapeutic strategy without reporting empirical data, clinical trials, or experimental validation.

AUG 12, 2026 · JOURNAL ARTICLE

Next-Generation Sequencing Refines Diagnosis and Expands Precision Medicine Opportunities in Soft Tissue Sarcomas

International Journal of Molecular Sciences

Retrospective single-centre biobank study of NGS diagnostic utility in a small, heterogeneous cohort without a prospective validation arm, comparator cohort, or clinical outcome data; demonstrates feasibility and diagnostic reclassification but lacks the rigor needed to claim practice change.

AUG 10, 2026 · JOURNAL ARTICLE

Advanced non-small cell lung cancer with SMARCA4 deficiency: a case report

Frontiers in Oncology

A single case report of an uncommon tumor type with no control group, describing one patient's response and outcome; contributes descriptive data but cannot establish efficacy or guide practice.

AUG 8, 2026 · JOURNAL ARTICLE

Complexities, challenges, and clinical implications of small cell lung cancer

Discover Oncology

This is a narrative review synthesizing current knowledge of SCLC biology, subtypes, therapeutic challenges, and research gaps to inform clinical and research practice.

AUG 8, 2026 · JOURNAL ARTICLE

Nuclear export inhibition activates TP53 pathways and is a potent therapeutic strategy in atypical teratoid rhabdoid tumors

Neuro-oncology Advances

Sound preclinical study with patient-derived models and in vivo validation showing XPO1 inhibition activates TP53 and reduces tumor burden, but lacks clinical trial data and human efficacy evidence.