Loading
Closed-loop tACS / Depression Major Depressive Disorder / Transcranial Alternating Current Stimulation · Interventional Study
ClinicalTrials.gov · August 18, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a completed feasibility study of a closed-loop transcranial alternating current stimulation device for major depressive disorder, designed to evaluate technical performance and device accuracy rather than clinical efficacy. No results have been posted in this registry record, so clinical benefit cannot be assessed.
Interventional, Randomized, Parallel, Triple masking, Device Feasibility purpose. Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation; age from 18 Years; to 70 Years. Intervention: Active Closed-loop tACS. Compared with: Sham Closed-loop tACS — Sham Comparator. n = 40. 1 site: United States.
This is a completed feasibility study of a closed-loop transcranial alternating current stimulation device for major depressive disorder, designed to evaluate technical performance and device accuracy rather than clinical efficacy. No results have been posted in this registry record, so clinical benefit cannot be assessed.
No results posted in registry record; clinical efficacy and safety data not available. No adverse event data or depression symptom changes reported.
This registry record does not report results and therefore cannot guide clinical practice. Clinicians should await publication of outcomes data to assess whether closed-loop tACS improves depressive symptoms.
This is a completed feasibility study of a closed-loop brain stimulation device with primary endpoints focused on technical performance and device accuracy, not clinical outcomes; results are not yet reported in this registry record.
As stated by the source record.
Quoted from the source exactly as published.
This registry record does not report results and therefore cannot guide clinical practice. Clinicians should await publication of outcomes data to assess whether closed-loop tACS improves depressive symptoms.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT06874374). This is a study registration, not published results. Lead sponsor: Pulvinar Neuro, LLC. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 40 participants (ACTUAL). Conditions: Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation. Interventions: DEVICE: Closed-loop tACS; DEVICE: Sham Comparator. Primary outcome measures: Correct Assignment by Device of Study Arm , 5 days; Accuracy of Device Study Arm Parameters by Device , 5 days; Accuracy of Stimulation Initiation Based on EEG by Device , 5 days; Accuracy of Device Logs Uploaded to Cloud by Device , 5 days. Brief summary: The purpose of this research study is to study a closed-loop transcranial alternating current stimulation (tACS) device to evaluate feasibility of the product in a clinical trial and collect preliminary data on potential effects on symptoms of depression in people with major depressive disorder.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.