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Depression / Cognitive Training / Sham Training · Interventional Study
ClinicalTrials.gov · August 19, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned interventional study registered at ClinicalTrials.gov testing whether computer-based cognitive training can enhance or extend the effects of ketamine or esketamine in patients with depression. No results have been reported in this registry record. The study is currently recruiting and remains in progress.
Interventional, Randomized, Parallel, Quadruple masking, Treatment purpose. Depression; age from 18 Years; to 80 Years. Intervention: Cognitive Training. Compared with: Sham Training — Sham Comparator. n = 600. 3 sites: United States.
This is a planned interventional study registered at ClinicalTrials.gov testing whether computer-based cognitive training can enhance or extend the effects of ketamine or esketamine in patients with depression. No results have been reported in this registry record. The study is currently recruiting and remains in progress.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Results from this study are not yet available. Clinicians should await outcome publication to assess whether cognitive training adjunctively enhances or prolongs ketamine/esketamine response in depression.
This is a registry record for a recruiting interventional study with no reported results; it describes a planned trial design and objectives only.
As stated by the source record.
Quoted from the source exactly as published.
Results from this study are not yet available. Clinicians should await outcome publication to assess whether cognitive training adjunctively enhances or prolongs ketamine/esketamine response in depression.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT06526078). This is a study registration, not published results. Lead sponsor: University of Pittsburgh. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 600 participants (ESTIMATED). Conditions: Depression. Interventions: BEHAVIORAL: Cognitive Training; BEHAVIORAL: Sham Training. Primary outcome measures: Montgomery Asberg Depression Rating Scale: During (Es)Ketamine Induction , Trajectories from baseline through end of 'induction phase' treatments (up to max of 12 weeks); Montgomery Asberg Depression Rating Scale: After (Es)Ketamine Induction , Trajectories from final 'induction phase' treatment through 4 weeks post-induction. Brief summary: In a sample of patients already receiving ketamine (or esketamine) treatment as part of their clinical care, this project seeks to test whether we can enhance and/or extend (es)ketamine's rapid effects by introducing helpful information delivered by a computer-based cognitive training protocol. This work could ultimately lead to the ability to treat depression more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.