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MagVita / Depression · Observational Study
ClinicalTrials.gov · September 11, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry record for an active observational study examining whether EEG parameters (frontal alpha asymmetry and functional connectivity) change in response to rTMS and whether these changes predict clinical responder status in depression. No results are reported in this registry entry, and the study remains in recruitment or analysis phase.
Observational. Depression; age from 18 Years; to 80 Years. Intervention: patients with depression. n = 30. 1 site: United States.
This is a registry record for an active observational study examining whether EEG parameters (frontal alpha asymmetry and functional connectivity) change in response to rTMS and whether these changes predict clinical responder status in depression. No results are reported in this registry entry, and the study remains in recruitment or analysis phase.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
If results become available, this study may help identify which depressed patients are likely to respond to rTMS based on baseline or early EEG signatures, potentially personalising treatment selection. However, the observational design and small sample limit immediate clinical applicability.
This is a registry record for an active observational study with no reported results; it describes a planned exploratory analysis of EEG biomarkers to predict rTMS response in depression, which is hypothesis-generating work without outcome data.
As stated by the source record.
Quoted from the source exactly as published.
If results become available, this study may help identify which depressed patients are likely to respond to rTMS based on baseline or early EEG signatures, potentially personalising treatment selection. However, the observational design and small sample limit immediate clinical applicability.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT05424224). This is a study registration, not published results. Lead sponsor: Florida International University. Recruitment status: ACTIVE_NOT_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 30 participants (ESTIMATED). Conditions: Depression. Interventions: DEVICE: MagVita. Primary outcome measures: EEG parameters to asses the change , Session 1(baseline), Session 10 ( after 2 weeks of treatment), and 30 ( treatment completion). Brief summary: Repetitive Transcranial Magnetic Stimulation (rTMS) is a promising, novel, non-invasive therapy for depression. In fact, there is an FDA-approved depression protocol to stimulate the dorsolateral prefrontal cortex (dlPFC). Its efficacy and safety have improved significantly with continued research and clinical experience. However, it is not known how to identify potential patients who would benefit most from treatment. The primary goal of this study is to determine if changes in specific electroencephalogram (EEG) parameters after treatment can predict whether patients are responders or non-responders to rTMS. The second objective is to analyze changes in the functional connectivity of specific brain regions in responders compared to non-responders. The hypothesis is that through rTMS treatment, investigators will be able to increase the activity in the frontal region that includes the dorsolateral prefrontal cortex (DLPFC). Scalp EEG signals will be processed in order to compare EEG brain connectivity and Frontal alpha asymmetry index (FAA) to determine if there are differences before and after the treatment. EEG FAA is usually calculated by subtracting the right-side EEG power estimates from the respective counterpart on the other side. According to literature, depressive patients seem to have comparatively higher left frontal alpha power. Cortical activity is related to a reduced EEG power, which is reflected in depressed subjects. On the other hand, higher alpha power could also be interpreted as inhibition. Investigators will try to delineate changes in resting EEG functional connectivity before and after high-frequency left prefrontal rTMS, by using biomarkers such as: time/frequency connectivity, Alpha asymmetry index, among others. TMS also allows cortical properties, such as excitability, inhibition, oscillatory activity and connectivity to be directly probed within a specific region of the cortex. Other studies suggest that alterations in gamma oscillations in the dorsolateral prefrontal cortex and neighboring frontal regions are also potential shared biomarkers in psychiatry, highlighting the potential of EEG signals to help identify suitable biomarkers. Given its relative low cost and ease of use, when compared to brain imaging tools such as magnetic resonance imaging (MRI) or positron emission tomography (PET), EEG could be added to the clinical study so that precise neurophysiological changes before and after treatments can be assessed.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.