Major Depressive Disorder / rTMS · Interventional Study

Individualized Targeting and Neuromodulation of Late-Life Depression

ClinicalTrials.gov · August 4, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a planned open-label, single-arm study of individualized rTMS targeting guided by fMRI in late-life depression, currently recruiting. No efficacy or safety results are reported in this registry record; the study examines anterior cingulate cortex connectivity as a primary neuroimaging outcome at week 3 post-treatment.

What was studied

Interventional, Single Group, Open label, Treatment purpose. Major Depressive Disorder; age from 60 Years; to 79 Years. Intervention: rTMS. n = 24. 1 site: United States.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

This registry record documents a planned mechanistic study, not clinical outcomes. Clinicians should await publication of results to evaluate whether individualized rTMS targeting based on fMRI improves treatment response in late-life depression.

Plain-language summary

This is an active, single-arm interventional registry record with no reported results; it describes a planned study of individualized rTMS targeting in late-life depression using fMRI.

Study design

As stated by the source record.

MethodsPrimary outcome measure: Anterior Cingulate Cortex (ACC) Connectivity (assessed at Week 3 post-treatment assessment)

DesignInterventional, Single Group, Open label, Treatment purpose

PopulationMajor Depressive Disorder; age from 60 Years; to 79 Years

Sample size24

InterventionrTMS

Setting1 site: United States

Reported figures

Quoted from the source exactly as published.

Planned enrollment24

Primary outcome measureAnterior Cingulate Cortex (ACC) Connectivity

Assessment timepointWeek 3 post-treatment

Clinical bottom line

Caveats

No results reported; study is in active recruitment phase.
Single-arm, open-label design limits causal inference and cannot establish efficacy compared to placebo or standard rTMS.
Primary outcome is neuroimaging connectivity, not clinical symptom improvement or remission.
Sample size (n=24) is small; no power calculation or secondary clinical outcomes reported in this registry record.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

limited

Open-label, single-arm design; no control arm or blinding.

Directness

moderate

Directly addresses late-life depression treatment; primary outcome is neuroimaging connectivity.

Consistency

insufficient

Registry record only; no results reported; consistency cannot be assessed.

Risk of bias

limited

Open-label design and lack of control arm increase bias risk; no blinding described.

Sample adequacy

limited

Planned enrollment 24 participants; small sample size for clinical efficacy claims.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT04543773). This is a study registration, not published results. Lead sponsor: University of New Mexico. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 24 participants (ESTIMATED). Conditions: Major Depressive Disorder. Interventions: DEVICE: rTMS. Primary outcome measures: Anterior Cingulate Cortex (ACC) Connectivity , Week 3 post-treatment assessment. Brief summary: An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

Major Depressive DisorderUniversity of New MexirTMSNCT04543773