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Urinary Tract Infections Management · Journal article
Journal of Infection and Public Health · September 1, 2026
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This is a single-centre cross-sectional survey of uropathogenic E. coli isolates from 38 UTI cases in Bangladesh, documenting high prevalence of multidrug and extensively drug-resistant phenotypes, resistance genes (blaOXA, blaCTX-M, qnrA), virulence genes (crl, uidA, csgA), and biofilm formation. The study identifies strong statistical correlation between resistance gene load and antibiotic resistance index (rₛ = 0.719, p<0.001) and association of phylogenetic group B2 with virulence and biofilm traits, but does not test clinical interventions or patient outcomes.
Cross-sectional molecular epidemiology survey. Patients presenting to the diagnostic outpatient department of Mymensingh Medical College, Mymensingh, Bangladesh, with urine samples submitted for culture. Of 718 samples, 125 (17.41%) showed significant bacteriuria confirming UTI; E. coli was identified in 38 (30.4%).. n = 38. Mymensingh Medical College, Mymensingh, Bangladesh.
E. coli identified in 38 of 125 bacteriuria cases (30.4%); 66% MDR and 34% XDR Resistance: meropenem and amoxicillin 100%, imipenem 23.7%, nitrofurantoin 7.9% blaOXA (81.6%), blaCTX-M (55.3%), and qnrA (89.5%) most prevalent resistance genes
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This surveillance report documents the burden of MDR and XDR uropathogenic E. coli in a single institution in Bangladesh and identifies virulence and resistance gene profiles. While it does not evaluate treatment or outcomes, the high prevalence of resistance to β-lactams and fluoroquinolones and strong biofilm-forming capacity suggests a challenging clinical problem that warrants empirical therapy review and infection control vigilance in this setting.
Single-centre cross-sectional surveillance study of bacterial isolates with descriptive and correlational findings; no interventional design, no clinical outcomes, and no comparison group to establish causation or clinical impact.
As stated by the source record.
Quoted from the source exactly as published.
This surveillance report documents the burden of MDR and XDR uropathogenic E. coli in a single institution in Bangladesh and identifies virulence and resistance gene profiles. While it does not evaluate treatment or outcomes, the high prevalence of resistance to β-lactams and fluoroquinolones and strong biofilm-forming capacity suggests a challenging clinical problem that warrants empirical therapy review and infection control vigilance in this setting.
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Background Multidrug-resistant (MDR) Escherichia coli mediated urinary tract infections (UTIs) are an increasing public health concern, especially in low- and middle-income nations. This study aimed to determine the prevalence, antimicrobial resistance and virulence profile, biofilm forming ability with phylogenetic distribution and genetic diversity of uropathogenic E. coli (UPEC) isolated from UTI patients. Methods A total of 718 urine samples were collected from the diagnostic outpatient department of Mymensingh Medical College, Mymensingh, Bangladesh. Samples were analyzed using standard culture technique, and E. coli was identified by MALDI-TOF MS and PCR. Phenotypic antibiotic resistance was detected by the disc diffusion method. Both CRA and CVMP techniques were used to identify the biofilm forming ability. Virulence and resistance genes were identified by PCR. Genetic diversity was studied through phylogrouping, ERIC-PCR, and sequencing of 16 s rRNA gene. Result 125 (17.41%) samples showed significant bacteriuria and were confirmed as UTI cases. E. coli was identified in 38 (30.4%) of these cases and most of the isolates were recovered from females (63.2%) and individuals aged 15-35 years (47.4%). High resistance was observed against meropenem (100%) and amoxicillin (100%), while nitrofurantoin (7.9%) and imipenem (23.7%) had the lowest resistance rate. All of the study isolates were either MDR (66%) or XDR (34%). bla OXA (81.6%), bla CTX-M (55.3%), and qnr A (89.5%) were most prevalent resistance genes. A strong positive correlation (rₛ = 0.719, p<0.001) was found between resistance gene load and the multiple antibiotic resistance (MAR) index. crl (100%), uid A (100%), and csg A (94.7%) were highly prevalent virulence genes. Approximately 85% of isolates were biofilm producer. Phylogenetic group B2 (36.82%) was predominant and significantly associated with virulence gene carriage and biofilm formation. Furthermore, ERIC PCR revealed a considerable genetic variability among the study isolates. Conclusion These findings highlight the alarming spread of MDR and XDR E. coli strains with high virulence potential, emphasizing the need for continuous monitoring and judicious antibiotic use.
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