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Depression · Observational Study
ClinicalTrials.gov · August 7, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a prospective observational cohort study of medical interns designed to investigate gene-stress interactions in depression, with planned enrollment of 25,000 participants and depression assessment at 0, 3, 6, and 12 months of internship. No results are posted in this registry record; the study is currently enrolling by invitation.
Observational. Depression; accepts healthy volunteers. Intervention: 2020; 2019; 2018; 2017; 2016; 2015; 2014; 2013; 2012; 2011; 2010; 2009; 2008; 2007; 2021; 2022; 2023; 2024; 2025; 2026. n = 25,000. 1 site: United States.
This is a prospective observational cohort study of medical interns designed to investigate gene-stress interactions in depression, with planned enrollment of 25,000 participants and depression assessment at 0, 3, 6, and 12 months of internship. No results are posted in this registry record; the study is currently enrolling by invitation.
Results are not yet reported in this registry record; no efficacy, safety, or effect size data are available.
The source did not state who this applies to in practice.
This is a registry record for an ongoing observational study with no results yet reported; enrollment is active and outcome assessment is planned but not yet complete.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT01809080). This is a study registration, not published results. Lead sponsor: University of Michigan. Recruitment status: ENROLLING_BY_INVITATION. Study type: OBSERVATIONAL. Enrollment: 25000 participants (ESTIMATED). Conditions: Depression. Primary outcome measures: Assess the change in rates of depression among medical interns. , Months 0, 3, 6, and 12 of Intern Year. Brief summary: Retrospective studies have established a strong correlation between reports of life stress and depression. Investigators have begun to further explore this relationship by examining the role of gene x stress interactions in the pathogenesis of depression. In a recent landmark study, Caspi and colleagues (2003) reported an interaction between a serotonin transporter promoter polymorphism and life stress in the development of depression. This finding has been replicated in some but not all follow up studies. Despite the initial promise of these results, the ability to draw definitive conclusions is compromised by significant study design limitations: 1) retrospective design 2) a focus on acute rather than chronic stress 3) substantial variation in the character and intensity of stress between subjects. Medical internship is a period filled with predictable and high levels of chronic uncontrolled stress. Rates of depression among interns are elevated compared to the general population. In this study, we aim to utilize the predictable and consistent stress of internship to investigate the relationship between stress, genes and depression with a prospective study design that bypasses some of the pitfalls of previous studies.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.