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Diabetes, Cardiovascular Risks, and Lipoproteins / Adipokines, Inflammation, and Metabolic Diseases · Journal article
International Journal of Health and Pharmaceutical · September 9, 2026
Early or partial results. Treat as a signal, not a conclusion.
This cross-sectional study of 50 ischemic stroke patients reports a statistically significant association between overweight/obesity and elevated TG/HDL ratio (OR 5.833, 95% CI 1.387–24.539, p=0.011). The study is observational and descriptive; it does not establish causality, uses purposive sampling that may introduce bias, and is underpowered to support clinical decision-making.
Cross-sectional analytical observational study. Ischemic stroke patients at RSUD Kabupaten Tangerang in 2025; predominantly male; mean age 61.60±9.05 years; high prevalence of hypertension and diabetes mellitus.. n = 50. RSUD Kabupaten Tangerang, Indonesia.
Mean age 61.60±9.05 years; predominantly male; high prevalence of hypertension and diabetes mellitus 68% of patients were overweight or obese; 78% had high TG/HDL ratio Significant association between BMI and TG/HDL ratio: OR 5.833 (95% CI 1.387–24.539), p=0.011; Fisher's Exact p=0.024
Absolute risk reduction, number needed to harm/treat, and temporal relationship between BMI and stroke onset not reported.
This study suggests an association between elevated BMI and dyslipidemia (TG/HDL ratio) in ischemic stroke patients, consistent with established pathophysiology of atherosclerosis. However, the cross-sectional design and small purposively sampled cohort do not support causal inference or clinical practice change; results require confirmation in larger, well-designed studies.
Cross-sectional observational study with purposive sampling of 50 patients showing an association between BMI and TG/HDL ratio in ischemic stroke, but lacking a comparator group and causal inference capacity.
As stated by the source record.
Quoted from the source exactly as published.
This study suggests an association between elevated BMI and dyslipidemia (TG/HDL ratio) in ischemic stroke patients, consistent with established pathophysiology of atherosclerosis. However, the cross-sectional design and small purposively sampled cohort do not support causal inference or clinical practice change; results require confirmation in larger, well-designed studies.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Introduction:Stroke is a leading cause of long-term disability and mortality worldwide, particularly in developing countries. Dyslipidemia, especially the triglyceride to high-density lipoprotein ratio (TG/HDL), and body mass index (BMI) play important roles in cardiovascular disease pathogenesis, including ischemic stroke. Methods:This analytical observational study used a cross-sectional design based on medical records of ischemic stroke patients at RSUD Kabupaten Tangerang in 2025. A total of 50 patients were selected from 98 using purposive sampling. Variables included BMI, TG/HDL ratio, age, sex, hypertension, and diabetes mellitus. The data were analyzed using Chi-Square, Fisher's Exact tests, and risk estimate. Results:The mean age was 61.60±9.05 years. Most patients were male, with a high prevalence of hypertension and diabetes mellitus. A total of 68% were overweight/obese and 78% had high TG/HDL ratio. A significant association was found (p=0.011; Fisher's Exact p=0.024) with OR 5.833 (95% CI: 1.387–24.539). Discussion:The predominance of elderly patients with vascular comorbidities highlights the role of degenerative and metabolic factors in ischemic stroke. A higher TG/HDL ratio in overweight/obese patients reflects an atherogenic lipid profile associated with increased BMI. This condition, mediated by visceral fat accumulation, insulin resistance, and chronic inflammation, contributes to atherosclerosis underlying ischemic stroke.
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