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Tryptophan and Brain Disorders / Sleep and Related Disorders · Journal article
Frontiers in Psychiatry · August 5, 2026
Raises a question worth testing. It does not answer one.
This is a narrative review that constructs an integrated mechanistic framework linking circadian rhythm disruption to anxiety and depression through five key pathways (SCN-limbic circuit, HPA axis, immune inflammation, neurotransmitter plasticity, gut-brain axis). The source proposes circadian disruption as a core pathophysiological mechanism rather than a secondary symptom, and suggests chronotherapies and personalized intervention approaches, but does not report primary evidence, effect sizes, or comparative clinical trial outcomes to support practice change.
Narrative review. Patients with anxiety and depressive disorders.
Circadian rhythm disruption identified as a core pathophysiological mechanism rather than mere epiphenomenon in anxiety and depression Five key mechanistic pathways proposed linking disruption to emotional and sleep abnormalities Chronotherapies (light therapy, melatonin) summarized as actionable interventions
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The review argues for reconceptualizing circadian disruption from a secondary symptom to a therapeutic target in mood and anxiety disorders, supporting integration of circadian medicine into psychiatric practice. However, no specific clinical recommendations, effect sizes, or outcome data are provided to guide immediate practice changes.
A narrative review synthesizing mechanistic pathways and proposing a conceptual framework; does not report primary experimental evidence, effect sizes, or comparative clinical outcomes.
As stated by the source record.
The review argues for reconceptualizing circadian disruption from a secondary symptom to a therapeutic target in mood and anxiety disorders, supporting integration of circadian medicine into psychiatric practice. However, no specific clinical recommendations, effect sizes, or outcome data are provided to guide immediate practice changes.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.
Anxiety and depressive disorders impose a heavy global burden. Although sleep disturbances have traditionally been regarded as secondary symptoms of these conditions, converging evidence now implicates circadian rhythm disruption as a core pathophysiological mechanism rather than a mere epiphenomenon. This review systematically explores the circadian system and constructs an integrated framework linking disruption to the synergistic dysregulation of multiple pathways and subsequent emotional/sleep abnormalities. We systematically examine five key mechanistic pathways: the SCN-limbic circuit, HPA axis, immune inflammation, neurotransmitter plasticity, and the gut-brain axis. Furthermore, we define actionable subtypes of disruption, summarize chronotherapies (e.g., light therapy, melatonin), and analyze current controversies regarding causality. Finally, we propose future directions, including multi-omics sampling and personalized intervention algorithms. By integrating evidence linking circadian disruption to anxiety/depression, this paper highlights its central mechanistic value, providing theoretical support for precision psychiatry and the integration of circadian medicine.
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