AUG 7, 2026 · JOURNAL ARTICLE
Identificationof Tumor Hypoxia-Activated Degradation-TargetingChimeras
Journal of Medicinal Chemistry
This is a proof-of-concept chemical synthesis and mechanism study demonstrating a novel drug design strategy in cells and xenografts, lacking clinical endpoints or comparison to standard therapy.
Study details
DesignPreclinical chemical synthesis and in vitro…
InterventionCompound 11f, an HDTAC incorporating a hypo…