Ferroptosis and Cancer Prognosis

SEP 10, 2026 · JOURNAL ARTICLE

Molecular subgroups and biomarker guided precision immunotherapy in triple-negative breast cancer: advances, challenges, and future directions

Frontiers in Immunology

A comprehensive review integrating evidence from trials and biomarker studies to propose a precision immunotherapy framework for TNBC, addressing current standards and unresolved clinical challenges.

SEP 10, 2026 · JOURNAL ARTICLE

Ciprofol induces ferroptosis and enhances anti-PD-1 efficacy via USP1-mediated GPX4 ubiquitination in hepatocellular carcinoma

Biology Direct

Mechanistic preclinical study with in vitro and mouse models showing ciprofol induces ferroptosis and enhances anti-PD-1 efficacy in HCC; no human clinical data or phase 1 trial reported, limiting evidence strength despite sound experimental design.

SEP 10, 2026 · JOURNAL ARTICLE

l-rhamnose suppresses triple-negative breast cancer via GSTM5-mediated ferroptosis

Discover Oncology

Mechanistic study in cell lines and mouse xenografts with a single candidate agent; no human data, no comparator arm, and no clinical endpoints reported.

SEP 10, 2026 · JOURNAL ARTICLE

The deubiquitinating enzyme regulatory network in malignant progression of breast cancer encompasses mechanisms of action, clinical significance and emerging therapeutic targets

Discover Oncology

This is a comprehensive narrative review synthesizing mechanistic and preclinical findings on deubiquitinases in breast cancer, with no clinical trial data, prospective validation, or regulatory approval to support practice change.

SEP 10, 2026 · JOURNAL ARTICLE

An Atlas of Specificity Protein 1 in Oral Cancer: Networks, Therapeutics, and Priorities: A Scoping Review and scRNA-seq Analysis

International Dental Journal

A scoping review synthesizing preclinical and mechanistic evidence on Sp1 in OSCC with scRNA-seq analysis, raising translational questions but reporting no clinical trials or human efficacy data.

SEP 10, 2026 · JOURNAL ARTICLE

The Emerging Role of Ferroptosis in Pediatric Cancer Biology and Therapy

International Journal of Molecular Sciences

This is a narrative review summarizing preclinical mechanistic evidence and emerging concepts about ferroptosis in pediatric cancer, without reporting original clinical trial data, efficacy comparisons, or definitive human outcomes.

SEP 9, 2026 · JOURNAL ARTICLE

Prognostic and immunobiological relevance of an onco-immune signature in clear cell renal cell carcinoma

Clinical and Experimental Medicine

A retrospective derivation and validation study identifying a three-gene prognostic score in ccRCC with independent association to overall survival; sound design but limited by retrospective nature, single-center derivation cohort, and lack of prospective validation.

SEP 9, 2026 · JOURNAL ARTICLE

HSP90AA1 Knockdown Enhances Doxorubicin Sensitivity by Promoting Immunogenic Cell Death-Related Signaling and Immune-Related Tumor Microenvironment Remodeling in Breast Cancer

Cancers

Experimental validation in cell lines and a single syngeneic mouse model of a candidate target, lacking human efficacy data, phase 1 trial, or clinical translation to support practice change.