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Anika Gowda

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

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AUG 13, 2026 · JOURNAL ARTICLE

SPEN inactivation drives resistance to androgen receptor pathway inhibitors in metastatic prostate cancer

Clinical Cancer Research

Rigorous multi-level evidence (functional screens, large clinico-genomic cohort analysis with survival endpoints, and independent rapid autopsy validation) demonstrating SPEN inactivation as a biomarker associated with reduced ARPI benefit in metastatic prostate cancer.

Strong EvidencePeter Yong Prostate Cancer Treatment and Research Prostate Cancer Diagnosis and Treatment

Reported

SPEN mutation prevalence pre-trea…2.1%

SPEN mutation prevalence post-ARPI3.6%

p-value for enrichment0.001

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