JUL 28, 2026 · JOURNAL ARTICLE
mRNA Vaccines Enhance Tumor Control and Synergize with 4-1BB Costimulatory Therapy 2309043
The Journal of Immunology
A controlled preclinical study demonstrating synergy between mRNA-LNP vaccination and 4-1BB costimulation in a single tumor model, with mechanistic insight but limited to mouse melanoma.
Reported
Tumor cell challenge dose1x10^6 B16 melanoma cells
4-1BB antibody dose50 μg
Timing of immunizationFive days post-tumor challenge