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Sean-Luc Shanahan

Massachusetts Institute of Technology

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JUL 28, 2026 · JOURNAL ARTICLE

Messenger RNA vaccination produces functionally robust yet peripherally restricted tumor-specific cytolytic effector cells 2260948

The Journal of Immunology

Mechanistic murine study with flow cytometry and imaging endpoints identifying a potential barrier to mRNA vaccine efficacy; results are hypothesis-generating rather than definitive for clinical practice.

PreliminaryLeena Hamad Immunotherapy and Immune Responses Chemokine Receptors and Signaling

Reported

Splenocyte clearance99%

Clearance timeframe20 hours

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