Researcher

Jun Li

Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

2 developments in the corpus

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JUL 28, 2026 · JOURNAL ARTICLE

Genome-wide CRISPR Identification of Regulators Governing the NLRP3 Inflammasome 2331537

The Journal of Immunology

This is a discovery-phase functional genomics screen that identifies candidate regulators of NLRP3 inflammasome activation in a cell line model; it raises mechanistic questions and nominates targets for future validation rather than testing a clinical hypothesis or providing evidence ready for therapeutic application.

Hypothesis-GeneratingSumit Chanda Patricia Hsieh Hong He

Study details

DesignGenome-wide CRISPR-Cas9 knockout screen wit…

InterventionGenome-wide CRISPR-Cas9 knockout of candida…

ComparatorCells sorted by ASC speck formation (ASC-GF…

JUN 23, 2026 · OBSERVATIONAL STUDY WITH TARGET TRIAL EMULATION

Amino acid infusion and acute kidney injury after aortic surgery: a multicenter observational study with target trial emulation.

Renal Failure

Observational study with target trial emulation found no significant association between amino acid therapy and AKI, though hypothesis-generating subgroup signal in older patients.

Insufficient InformationWeize Zhang Junjie Wang Renal Replacement Therapy

Reported

Sample size1,816

AKI incidence37.8% (n = 686)

30-day mortality1.6% (n = 29)