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Patricia Hsieh

Scripps Research Institute

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JUL 28, 2026 · JOURNAL ARTICLE

Genome-wide CRISPR Identification of Regulators Governing the NLRP3 Inflammasome 2331537

The Journal of Immunology

This is a discovery-phase functional genomics screen that identifies candidate regulators of NLRP3 inflammasome activation in a cell line model; it raises mechanistic questions and nominates targets for future validation rather than testing a clinical hypothesis or providing evidence ready for therapeutic application.

Hypothesis-GeneratingSumit Chanda Patricia Hsieh Hong He

Study details

DesignGenome-wide CRISPR-Cas9 knockout screen wit…

InterventionGenome-wide CRISPR-Cas9 knockout of candida…

ComparatorCells sorted by ASC speck formation (ASC-GF…

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