Drug or technology

Renal Replacement Therapy

2 developments in the corpus

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JUL 31, 2026 · JOURNAL ARTICLE

Safety and outcomes of dapagliflozin initiation in critically ill patients with acute kidney injury: A post-hoc analysis of the defender trial.

Journal of Critical Care

A post-hoc analysis from a controlled trial showing no safety signal for dapagliflozin in critically ill AKI patients, with near-neutral effects and physiological stability, but underpowered to detect clinically meaningful benefit or harm.

PromisingCaio A M Tavares Álvaro Rea-Neto Renal Replacement Therapy

Reported

28-day mortality (dapagliflozin v…38% vs 40%

Kidney replacement therapy (dapag…12% vs 18%

Composite death/KRT (dapagliflozi…41% vs 42%

JUN 23, 2026 · OBSERVATIONAL STUDY WITH TARGET TRIAL EMULATION

Amino acid infusion and acute kidney injury after aortic surgery: a multicenter observational study with target trial emulation.

Renal Failure

Observational study with target trial emulation found no significant association between amino acid therapy and AKI, though hypothesis-generating subgroup signal in older patients.

Insufficient InformationWeize Zhang Junjie Wang Renal Replacement Therapy

Reported

Sample size1,816

AKI incidence37.8% (n = 686)

30-day mortality1.6% (n = 29)