Immune Cells in Cancer

SEP 10, 2026 · JOURNAL ARTICLE

Sequential Mannose-Targeted Nanotherapy Orchestrates Tumor-Associated Macrophage Repolarization and Chemotherapeutic Response in Triple-Negative Breast Cancer

Acs Applied Bio Materials

Preclinical study in murine tumor model with surrogate endpoints (macrophage polarization, cytokine profile, cardiac markers) and no human data; promising mechanistic approach but requires clinical validation.

SEP 10, 2026 · JOURNAL ARTICLE

l-rhamnose suppresses triple-negative breast cancer via GSTM5-mediated ferroptosis

Discover Oncology

Mechanistic study in cell lines and mouse xenografts with a single candidate agent; no human data, no comparator arm, and no clinical endpoints reported.

SEP 10, 2026 · JOURNAL ARTICLE

The CCL2-CCR2 axis in primary lung cancer and pulmonary metastasis: from molecular mechanisms to therapeutic potentials

Frontiers in Immunology

A narrative review summarizing mechanistic evidence and preclinical/early translational data on the CCL2–CCR2 axis in lung cancer, without reporting original clinical trial results or definitive clinical outcomes.

SEP 10, 2026 · JOURNAL ARTICLE

Quantitative Systems Pharmacology Model Predicts Enhanced Antitumor Efficacy of Combined Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) and Programmed Cell Death Protein 1 (PD-1) Blockade in a Syngeneic Mouse Model of Breast Cancer

Acs Pharmacology & Translational Science

A mechanistic computational model of checkpoint-inhibitor combinations in mice that predicts synergy but lacks experimental validation of the proposed mechanisms in humans and does not address clinical efficacy or safety.

SEP 10, 2026 · JOURNAL ARTICLE

The single-cell immune atlas of bacterial pneumonia: from inflammatory cell infiltration to treatable cell states

Frontiers in Cellular and Infection Microbiology

A narrative reorganization of published single-cell datasets proposing a ranked hypothesis framework for host-directed therapy targets in bacterial pneumonia, without new primary data, validation, or clinical outcome evidence.

SEP 10, 2026 · JOURNAL ARTICLE

The Emerging Role of Ferroptosis in Pediatric Cancer Biology and Therapy

International Journal of Molecular Sciences

This is a narrative review summarizing preclinical mechanistic evidence and emerging concepts about ferroptosis in pediatric cancer, without reporting original clinical trial data, efficacy comparisons, or definitive human outcomes.

SEP 9, 2026 · JOURNAL ARTICLE

PET, Proteomics, and Immunophenotyping of Arterial Inflammation and Checkpoint Inhibition

JAMA Cardiology

Prospective cohort study with multimodal imaging and biomarker endpoints showing no detectable arterial inflammation with ICIs or VEGFIs, directly addressing an important but incompletely resolved mechanistic question; limited by modest sample size and surrogate endpoints rather than hard clinical outcomes.

SEP 9, 2026 · JOURNAL ARTICLE

The Development of Cellular Aging Models Based on AD-MSCs

Cells

In vitro mechanistic study establishing a cellular aging model and demonstrating senolytic activity of fisetin in a single-cell system; requires in vivo validation before clinical relevance can be assessed.