Researcher

Chao Ke

Department of Orthopedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

2 developments in the corpus

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AUG 9, 2026 · JOURNAL ARTICLE

Systematic Comparison of High‐Fat Diet– and Streptozotocin‐Induced Prediabetic Obese C57BL / 6J Mouse Models: A Sex‐Based Protocol Optimization Study

Diabetes Obesity and Metabolism

Protocol optimization study in animal models comparing five inbred mouse regimens; provides useful characterization for researchers but lacks clinical outcomes, human translation, or definitive evidence for therapeutic testing.

PreliminaryWei Zhang Yang Cao Yangkun Liu

Reported

HFD-STZ-L success rate73.3%

Male glucose/hepatic lipid deteri…Week 12

Female Pre-DM threshold timepoint16 weeks

JUN 22, 2026

KIF18A inhibitor prevents chromosomally unstable osteosarcoma growth by activating spindle assembly checkpoint.

Cancer Biology & Therapy

Preclinical cell-line and xenograft data showing anti-tumor activity of a KIF18A inhibitor in osteosarcoma models without human trial evidence.

PreliminaryYan Zhang Xenograft Model Antitumor Assays Spindle Assembly Checkpoint

Study details

DesignPreclinical cell-line and xenograft study

InterventionKIF18A knockout or KIF18A inhibitor AM-1882

ComparatorParental SJSA1 cells, chemotherapeutic drug…