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Spindle Assembly Checkpoint

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JUN 22, 2026

KIF18A inhibitor prevents chromosomally unstable osteosarcoma growth by activating spindle assembly checkpoint.

Cancer Biology & Therapy

Preclinical cell-line and xenograft data showing anti-tumor activity of a KIF18A inhibitor in osteosarcoma models without human trial evidence.

PreliminaryYan Zhang Xenograft Model Antitumor Assays Spindle Assembly Checkpoint

Study details

DesignPreclinical cell-line and xenograft study

InterventionKIF18A knockout or KIF18A inhibitor AM-1882

ComparatorParental SJSA1 cells, chemotherapeutic drug…

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