AUG 17, 2026 · JOURNAL ARTICLE
IRF1 in Adipocytes Is Associated with Insulin Signaling and Mitochondrial Homeostasis in Diet-Induced Obesity
International Journal of Molecular Sciences
A mechanistically detailed single-centre preclinical study using knockout mice and cell lines showing improved insulin signaling in adipocyte-specific IRF1 deficiency, but limited by lack of clinical translation, small sample size reporting, and surrogate endpoints rather than hard clinical outcomes.
Study details
DesignPreclinical mechanistic study: transgenic k…
InterventionAdipocyte-specific Irf1 gene knockout (via…
ComparatorWild-type controls (for mouse model); scram…