Researcher

Ying Zhou

Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.

2 developments in the corpus

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AUG 17, 2026 · JOURNAL ARTICLE

IRF1 in Adipocytes Is Associated with Insulin Signaling and Mitochondrial Homeostasis in Diet-Induced Obesity

International Journal of Molecular Sciences

A mechanistically detailed single-centre preclinical study using knockout mice and cell lines showing improved insulin signaling in adipocyte-specific IRF1 deficiency, but limited by lack of clinical translation, small sample size reporting, and surrogate endpoints rather than hard clinical outcomes.

PromisingChongxiu Sun Metabolism, Diabetes, and Cancer Ying Zhou

Study details

DesignPreclinical mechanistic study: transgenic k…

InterventionAdipocyte-specific Irf1 gene knockout (via…

ComparatorWild-type controls (for mouse model); scram…

JUN 7, 2026 · JOURNAL ARTICLE

Gut microbial metabolism of Flutamide attenuates its therapeutic efficacy against prostate cancer.

Gut Microbes

Mechanistic preclinical study with xenograft and clinical sample data identifying gut microbial metabolism as a contributor to flutamide resistance, with potential for personalized therapy but lacking clinical trial evidence of efficacy.

PromisingProstatic Neoplasms Xenograft Model Antitumor Assays Shujing Li

Reported

Metabolite activity in vitroNo anticancer activity