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A systematic review and meta-analysis of 8 small pediatric dietary intervention trials (200 children total) showing a significant increase in microbiota alpha-diversity and butyrate-producing bacteria, but with substantial heterogeneity, limited cardiometabolic outcome data, and acknowledged evidence gaps that prevent definitive clinical recommendations.
A narrative review synthesizing epidemiology, clinical phenotype, diagnosis, and management of AGS with emphasis on GI manifestations and public health recommendations, grounded in systematic literature search but not reporting original research findings.
A narrative review synthesizing mechanistic understanding of gut-liver axis dysregulation in MASLD, offering a framework for understanding disease pathways and therapeutic targets rather than reporting original evidence.
Systematic review of 6 small studies (220 patients, 6–12 month follow-up) showing improvements in fibrosis indices and metabolic markers, but short-term surrogate endpoints without hard liver outcomes or long-term durability data.
British Journal of Healthcare and Medical Research
A small retrospective case series (n=6) describing a temporal association between GLP-1RA initiation and pouchitis in surgically altered anatomy; raises a hypothesis rather than establishing causation or providing quantified risk.
Observational study demonstrating associations between gastrin-17 levels and GERD severity in comorbid disease, with moderate sample size and statistically significant correlations, but lacking a control arm and mechanistic intervention.
This is a mechanistic review synthesizing preclinical and indirect human evidence for diet–stress interactions at the gut barrier, explicitly stating that direct human evidence for true diet × stress barrier interaction remains limited and the framework should be treated as testable rather than established.
This is a narrative review article proposing a conceptual framework linking gut-brain interaction, psychosocial factors, and homeopathic treatment in pediatric constipation, without new empirical data or clinical trial evidence.