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A narrative review synthesizing heterogeneous evidence on treatment options for radiation-induced rectovaginal fistula, offering clinical guidance but acknowledging low overall certainty and lack of direct evidence from RI-RVF populations for most interventions.
Multicenter external validation of machine learning models for a clinically relevant surrogate endpoint (LARS prediction) with robust discrimination (AUC 0.903) in a reasonable sample, but limited to retrospective design and post-hoc risk stratification rather than prospective clinical decision-making or hard outcomes.
A small retrospective case series (4 cases) combined with descriptive literature review synthesis; generates clinical insights for a rare disease but lacks control groups, prospective design, or quantified interventional outcomes to support definitive guidance.
A single case report of disseminated Nocardia farcinica infection in an immunosuppressed patient; valuable for clinical recognition but lacks comparative or quantitative evidence.
A single case report describing an uncommon clinical presentation; raises important clinical awareness about disseminated N. brasiliensis and antimicrobial resistance in a specific host, but cannot establish frequency, causation, or generalizable management principles.