Depressive Disorder

SEP 8, 2026 · INTERVENTIONAL STUDY

iACT & iTBS for Sleep Quality in Depressed Adolescents

ClinicalTrials.gov

This is a completed trial registry record with no posted results; the study design is sound but results remain unreported, making it an early-stage report that cannot yet inform clinical practice.

SEP 8, 2026 · OBSERVATIONAL STUDY

Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

ClinicalTrials.gov

Observational cross-sectional neuroimaging study with no results posted; designed to identify neural biomarkers in depression but recruitment completion alone does not constitute evidence of efficacy or clinical utility.

AUG 25, 2026 · JOURNAL ARTICLE

Childhood trauma and suicide ideation and attempts: Examining the mediating role of psychosocial, personality, lifestyle and biological factors.

Journal of Affective Disorders

A well-designed cross-sectional mediation analysis in a large clinical sample identifies plausible pathways between childhood trauma and suicide outcomes, but cross-sectional design prevents causal inference and limits actionability.

AUG 15, 2026 · JOURNAL ARTICLE

Impact of psychiatric medication on suicide reattempt risk in patients with depression: A retrospective cohort study using national health insurance data in Korea.

Journal of Affective Disorders

A rigorous observational study with propensity-score adjustment showing a clear short-term protective effect (one-year reattempt reduction) in a clinically relevant population, but limited by observational design, lack of long-term benefit, and age-specific effects that require confirmation.

AUG 14, 2026 · JOURNAL ARTICLE

Antipsychotic medication and the prevention of psychiatric emergencies in difficult-to-treat adolescent depression.

Journal of Affective Disorders

Large observational cohort study with propensity-score weighting comparing antipsychotics to antidepressants for a hard clinical outcome (psychiatric emergency visits/admissions) in adolescents with difficult-to-treat depression, showing increased risk with antipsychotics and consistent results across sensitivity analyses.

AUG 14, 2026 · INTERVENTIONAL STUDY

The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

ClinicalTrials.gov

This is an uncontrolled pilot study with very small planned enrollment (n=8) and no comparator arm, designed to test feasibility and gather preliminary data on a behavioral mobile app intervention for depression in African Americans.

AUG 14, 2026 · INTERVENTIONAL STUDY

Physiotherapy Intervention Program for Chronic Pain Associated With Depressive Disorder

ClinicalTrials.gov

This is a completed single-arm pre-post intervention study with no comparator group, evaluating a hybrid physiotherapy program in a small sample; results are not yet reported in this registry record.

AUG 10, 2026 · INTERVENTIONAL STUDY

Stereotactic Radiotherapy Treatment for Treatment-Resistant Depression

ClinicalTrials.gov

Small, single-center, uncontrolled interventional study with recruitment completed but no results posted in registry; design and sample size insufficient to support efficacy claims.