Signaling Pathways in Disease

SEP 5, 2026 · JOURNAL ARTICLE

PRMT7 restricts CD8+ T cells expansion via the NF-ΚB pathway

Nature Communications

A mechanistically sound study combining genetic and pharmacological approaches in mouse and human models, demonstrating PRMT7 inhibition enhances CD8+ T cell function, but limited by single tumor model and lack of phase-controlled clinical trial.

SEP 5, 2026 · JOURNAL ARTICLE

Design, Synthesis and in vitro Evaluation of Phthalimide-Anhydride Derivatives as MMP-9 Suppressors in Breast Cancer Therapy

Asian Journal of Chemistry

Early-stage in vitro chemical screening with molecular modelling; no animal efficacy data, significant toxicity concerns (LD50 Category 2), and the authors themselves call for further optimization before preclinical development.

AUG 11, 2026 · JOURNAL ARTICLE

Smyca-FOXM1 ribonucleoprotein complex promotes homologous recombination and tumor immune evasion to define a therapeutic target of triple-negative breast cancer

Journal of Biomedical Science

Mechanistic discovery study using cell assays, organoid and mouse models identifying Smyca-FOXM1 as a potential target, without clinical trial data or hard clinical outcomes to support therapeutic claims.