SEP 5, 2026 · JOURNAL ARTICLE
Design, Synthesis and in vitro Evaluation of Phthalimide-Anhydride Derivatives as MMP-9 Suppressors in Breast Cancer Therapy
Asian Journal of Chemistry
Early-stage in vitro chemical screening with molecular modelling; no animal efficacy data, significant toxicity concerns (LD50 Category 2), and the authors themselves call for further optimization before preclinical development.
Reported
Glide docking score (compound 5c)-4.632 kcal/mol
RMSD stability (100 ns MD)1.5–2.5 Å
IC50 compound 5c (MCF-7)27.89 µg/mL; 82.7 µM