Researcher

Kun Zhang

Department of Orthopedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

2 developments in the corpus

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SEP 7, 2026 · JOURNAL ARTICLE

Spin-state modulation at Fe-O-Cu interfaces enables dual ferroptotic-cuproptotic cancer therapy

Journal of Nanobiotechnology

This is a mechanistic and proof-of-concept study demonstrating a novel nanomaterial design principle in cancer cells and a mouse model, but lacks comparative efficacy data, clinical endpoints, or phase-appropriate trial design to support clinical recommendations.

Hypothesis-GeneratingSijie Shao Nanoparticle-based Drug Delivery You Pan

Study details

DesignPreclinical mechanistic and in vivo proof-o…

InterventionFeMOF/PtCu hybrid nanoparticles (MIL-88B(Fe…

JUN 22, 2026

KIF18A inhibitor prevents chromosomally unstable osteosarcoma growth by activating spindle assembly checkpoint.

Cancer Biology & Therapy

Preclinical cell-line and xenograft data showing anti-tumor activity of a KIF18A inhibitor in osteosarcoma models without human trial evidence.

PreliminaryYan Zhang Xenograft Model Antitumor Assays Spindle Assembly Checkpoint

Study details

DesignPreclinical cell-line and xenograft study

InterventionKIF18A knockout or KIF18A inhibitor AM-1882

ComparatorParental SJSA1 cells, chemotherapeutic drug…