Ovarian Function and Disorders

SEP 10, 2026 · JOURNAL ARTICLE

The role of intestinal microbial metabolites in polycystic ovary syndrome: mechanistic insights and intervention prospects

Frontiers in Endocrinology

This is a narrative review synthesizing mechanistic evidence and intervention strategies for gut microbiota in PCOS, providing expert summary rather than original data or a practice-changing trial.

SEP 10, 2026 · JOURNAL ARTICLE

Comparative Effects of Combined Inositols and Alpha-Lipoic Acid (ALA) On Metabolic, Hormonal, and Clinical Outcomes in Obese Hyperinsulinemic Women with Polyendocrine Metabolic Ovarian Syndrome (PCOS/PMOS): The Impact of Family History of Diabetes

Medical Times

A randomized double-blind trial with 96 participants showing dose-response improvements in insulin resistance, hormonal markers, and menstrual regularity over 24 weeks, but limited by single-center design, surrogate endpoints, and lack of hard clinical outcomes.

SEP 10, 2026 · JOURNAL ARTICLE

Comparison of live birth rates between calorie-restricted diet and metformin prior to ovulation induction therapy in women with polycystic ovary syndrome and overweight/obesity: a protocol for a multicenter, randomized comparative effectiveness trial

Frontiers in Public Health

This is a published protocol for an upcoming multicenter RCT; no results are presented, only the study design and rationale for a planned comparison of diet versus metformin in PCOS.

SEP 9, 2026 · JOURNAL ARTICLE

Defining metabolic heterogeneity in polyendocrine metabolic ovarian syndrome based on the MTHFR C677T polymorphism: the potential pathway role of homocysteine

Journal of Ovarian Research

A retrospective, cross-sectional genotyping study proposing a mechanistic pathway (MTHFR genotype → homocysteine → metabolic heterogeneity) without causal evidence; the authors acknowledge exploratory design and explicitly call for prospective validation.

SEP 8, 2026 · JOURNAL ARTICLE

BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF

International Journal of Molecular Sciences

This is a mechanistic review synthesizing evidence largely from rodent models and cultured systems to propose BMAL1 dysregulation as a unifying mechanism; direct causal evidence in humans is acknowledged as lacking, and clinical data are only consistent with, not proof of, the proposed dual mechanism.

SEP 6, 2026 · JOURNAL ARTICLE

Comparative evaluation of insulin resistance and adipokine status in men with hypogonadism associated with obesity

Andrology and Genital Surgery

A single-centre cross-sectional study with modest sample size and no control group for adipokine differences; correlational findings are hypothesis-generating rather than causal or practice-defining.

SEP 4, 2026 · JOURNAL ARTICLE

Study on Levels of Short Chain Fatty Acids in Follicular Fluid of Obese Women with Polycystic Ovarian Syndrome Compared with Normal-Weights

Iranian Journal of Diabetes and Metabolism

Small, uncontrolled cross-sectional study of a biomarker (SCFA levels) in follicular fluid with no healthy control group, measuring an association rather than a clinical outcome; authors acknowledge need for further studies.

SEP 3, 2026 · JOURNAL ARTICLE

Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model

Scientific Reports

A mixed mechanistic study combining human observational data with a targeted animal model, showing a significant human-animal disconnect that narrows but does not resolve the hypothesis about adiponectin and anxiety in PCOS.