SEP 8, 2026 · JOURNAL ARTICLE
BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF
International Journal of Molecular Sciences
This is a mechanistic review synthesizing evidence largely from rodent models and cultured systems to propose BMAL1 dysregulation as a unifying mechanism; direct causal evidence in humans is acknowledged as lacking, and clinical data are only consistent with, not proof of, the proposed dual mechanism.
Reported
Prevalence of obesity in reproduc…nearly one in three women worldwide