JUL 28, 2026 · JOURNAL ARTICLE
Monitoring antigen-specific T cell responses to B. burgdorferi 2253490
The Journal of Immunology
Proof-of-concept study in a mouse model using engineered bacteria and adoptive T cell transfer, demonstrating that in vitro T cell reprogramming can reduce bacterial burden, but findings are not yet translatable to human Lyme disease prevention or treatment.
Study details
DesignExperimental immunology study with adoptive…
InterventionEngineered B. burgdorferi expressing OVA ep…
ComparatorBb-control (non-OVA-expressing B. burgdorfe…