JUL 7, 2026 · JOURNAL ARTICLE
Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.
Biomaterials
Preclinical mouse study demonstrates a novel peptide-nanocomplex delivery system with improved lymph node targeting and prolonged antigen expression compared to lipid nanoparticles, with comparable neutralizing antibody responses and superior CD8+ T cell responses, but lacks human data and clinical validation.
Reported
Particle sizeunder 200 nm
Duration of mRNA expression (pept…up to 7 days
Duration of mRNA expression (LNPs)within 48 h