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Zongxi He

North Sichuan Medical University

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AUG 18, 2026 · JOURNAL ARTICLE

Evaluation of the safety and efficacy of 225Ac-PSMA-CY313 in metastatic castration-resistant prostate cancer: preliminary results

European Radiology Experimental

First-in-human, open-label, single-arm study of 16 heavily pretreated patients with surrogate and radiographic endpoints; demonstrates feasibility and signal but requires larger prospective validation before clinical impact can be determined.

PreliminaryProstate Cancer Treatment and Research Yekuan Shi Prostate Cancer Diagnosis and Treatment

Reported

Sample size16

PSA50 response rate37.5%

PSA50 response 95% CI15.2%–64.6%

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