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Population-based cohort study with adequate sample size showing that isolated tumor cells and nodal burden lack prognostic significance in endometrial cancer after adjustment for clinical and molecular factors, confirming that current nodal assessment practices may not require stratification by these markers.
An uncontrolled mechanistic study in a transgenic mouse model using human-derived extracellular vesicles as a pooled intervention, with modest neuropathological changes and no primary clinical endpoint, requires confirmation before clinical translation.