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M Matsumi

Hiroshima University

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SEP 1, 2026 · JOURNAL ARTICLE

286. Restoration by ketamine metabolites of cognitive and affective prosocial behaviors in a mouse model of depression

The International Journal of Neuropsychopharmacology

Uncontrolled, preclinical study in a mouse depression model with a mechanistic focus; demonstrates proof-of-concept for ketamine metabolites restoring prosocial behaviors but requires human clinical validation.

PreliminaryS Asano Tryptophan and Brain Disorders Neurotransmitter Receptor Influence on Behavior

Study details

DesignPreclinical mechanistic study in an animal…

InterventionAcute administration of (2R,6R)-hydroxynork…

ComparatorNaïve mice (baseline prosocial behavior); c…

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