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A narrative review summarizing mechanistic evidence and preclinical/early translational data on the CCL2–CCR2 axis in lung cancer, without reporting original clinical trial results or definitive clinical outcomes.
Large prospective cohort study with 107,363 participants, hard clinical endpoints (CLD diagnoses from linked medical records), clear dose-response relationships, and rigorous mediation analysis; robust but observational design limits causal inference.
This is a narrative review synthesizing mechanistic evidence about neural regulation in lung cancer, raising questions about therapeutic potential rather than reporting original empirical results or clinical outcomes.