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A narrative review synthesizing preclinical evidence and limited clinical data suggesting the entopeduncular nucleus as a therapeutic target in psychiatric and sleep disorders, but lacking controlled trials or definitive human efficacy data.
Rigorous longitudinal cohort study with 774 participants, 8-year follow-up, validated trajectory modeling, and multiple biomarker endpoints showing clear associations between sleep disturbance patterns and incident AD risk with strong effect sizes.
A well-designed comparative study with multivariable adjustment across two dementia cohorts identifies independent sleep phenotype differences with quantified effect sizes and confidence intervals.
A mechanistic review synthesizing bidirectional relationships between sleep disorders and metabolic disease via adipokine dysregulation, offering a framework for clinical integration but presenting no new primary data or controlled evidence.
Secondary analysis of an RCT with adequate sample size and mixed assessment methods (subjective and objective sleep measures) showing null findings for sleep disturbances as predictors of PTSD treatment response, with consistent results across both CPT and DBT-PTSD interventions.