Disease

Cognitive Decline

3 developments in the corpus

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Latest

Everything in the corpus, newest first.

AUG 20, 2026 · PHASE 2 TRIAL

Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers

ClinicalTrials.gov

This is a Phase 2 interventional trial registration with no results posted; the study is active but not yet recruiting and outcomes have not been reported.

PreliminaryCognitive Decline Akira Sekikawa NCT05741060

Reported

Planned sample size369

PhasePHASE 2

Primary outcome measure 1Change from baseline in arterial stiffness…

AUG 6, 2026 · PHASE 2 TRIAL

Dopaminergic Dysfunction in Late-Life Depression

ClinicalTrials.gov

Registry record of a completed Phase 2 interventional trial testing L-DOPA in late-life depression; no results are posted, so efficacy and safety remain unreported.

PreliminaryNCT04469959 Cognitive Decline Depressive Disorder, Treatment Resistant

Reported

Planned enrollment79

PhasePHASE 2

Primary outcome measuresChange in WAIS-R Digit Symbol Task Score, P…

AUG 6, 2026 · INTERVENTIONAL STUDY

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

ClinicalTrials.gov

This is a registry record for an ongoing interventional trial with no results posted; outcomes are planned but not yet reported, making evidence assessment impossible at this stage.

PreliminaryObstructive Sleep Apnea Cognitive Decline Positional therapy

Reported

Planned sample size200

Number of sites4

Study duration5 years