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Obstructive Sleep Apnea / Cognitive Decline / Positional therapy · Interventional Study
ClinicalTrials.gov · August 6, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned 5-year multicenter randomized trial designed to test whether effective OSA treatment improves memory and Alzheimer's disease biomarkers in cognitively normal older adults. No results have been posted in this registry record; the study is currently recruiting and remains in the data collection phase.
Interventional, Randomized, Parallel, Open label, Treatment purpose. Obstructive Sleep Apnea, Cognitive Decline; age from 55 Years; to 85 Years. Intervention: Waitlist control group. Compared with: 3-month OSA treatment — Active Comparator. n = 200. 4 sites: United States.
This is a planned 5-year multicenter randomized trial designed to test whether effective OSA treatment improves memory and Alzheimer's disease biomarkers in cognitively normal older adults. No results have been posted in this registry record; the study is currently recruiting and remains in the data collection phase.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a registry record for an ongoing interventional trial with no results posted; outcomes are planned but not yet reported, making evidence assessment impossible at this stage.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT05988385). This is a study registration, not published results. Lead sponsor: California Pacific Medical Center Research Institute. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 200 participants (ESTIMATED). Conditions: Obstructive Sleep Apnea, Cognitive Decline. Interventions: DEVICE: Positive airway pressure; DEVICE: Oral appliance therapy; DEVICE: Positional therapy. Primary outcome measures: Change in overnight memory retention on the A-B verbal paired associates task , 3 months; Change in overnight memory retention on the A-B verbal paired associates task , 12 months; Change in overnight memory retention on the A-B verbal paired associates task , 24 months; Change in Aβ42/ Aβ40 ratio , 3 months; Change in Aβ42/ Aβ40 ratio , 24 months; Change in Plasma P-tau181 , 3 months; Change in Plasma P-tau181 , 24 months; Change in P-tau217 , 3 months; Change in P-tau217 , 24 months; Change in Neurofibrilary light (NfL) , 3 months; Change in Neurofibrilary light (NfL) , 24 months; Preclinical Cognitive Composite Score , 3 months; Preclinical Cognitive Composite Score , 12 months; Preclinical Cognitive Composite Score , 24 months. Brief summary: The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from well-established sleep clinics at 4 academic medical centers, with newly diagnosed moderate-severe OSA. An expected 200 OSA patients will be then randomized to one of two groups: i) a 3-month OSA treatment by any combination of PAP, OAT, and positional therapy that results in an "effective" AHI4%\< 10/hour and AHI3A\<20/hour (see below); ii) a waitlist control group to receive treatment at the conclusion of the 3-month intervention period. Both groups will continue follow-up for 24 months on stable therapy to determine if sustained improvements in sleep are associated with improvement in cognitive function and AD biomarkers.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.