JUL 15, 2026 · JOURNAL ARTICLE
Aspirin alleviates long-term high-fat diet-induced depressive-like behavior in male mice via suppressing arachidonic acid-mediated microglial activation and neuroinflammation
Molecular Psychiatry
A rigorous preclinical study with multi-omics integration and mechanistic depth, but limited to male mice with surrogate behavioral endpoints; translational relevance to human depression remains unestablished.
Reported
Diet duration for robust behavior…≥10 weeks
Cytokines elevated in prefrontal…IL-6, TNF-α, CCL2