Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
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A rigorous meta-analysis of 48 RCTs with 48,765 participants showing no significant association between SGLT2 inhibitors and gastrointestinal neoplasm risk, with consistent null findings across multiple site-specific and subgroup analyses, though long-term safety remains incompletely characterized.
Prospective cohort study in a large Chinese population demonstrates significant associations between gestational cardiovascular health metrics and reduced adverse pregnancy outcomes, with clear dose-response relationships, but lacks a comparator intervention and cannot establish causation.