SEP 9, 2026 · JOURNAL ARTICLE
Docosahexaenoic Acid Enhances the Cytotoxic Effects of Enzalutamide and the PARP Inhibitor in Castration-Resistant Prostate Cancer Cell Lines
International Journal of Molecular Sciences
In vitro mechanistic study in cancer cell lines showing DHA enhances cytotoxicity of existing drugs; no clinical evidence, animal models, or human data; raises questions about potential synergy requiring confirmation in vivo.
Hypothesis-GeneratingAlana Della Torre da SilvaGuilherme Henrique TamarindoCancer, Lipids, and Metabolism
Study details
DesignIn vitro cell line study
InterventionDocosahexaenoic acid (DHA) alone or combine…
ComparatorEnzalutamide or PARP inhibitor alone; vehic…