Yan Chen

AUG 26, 2026 · JOURNAL ARTICLE

Engineered hypoimmunogenic iPSC-derived mesenchymal stromal cells secreting high levels of functional FVIII ameliorate the hemophilia A phenotype

Cellular and Molecular Life Sciences

Preclinical proof-of-concept in animal models using engineered iPSC-derived cells; lacks human efficacy data, safety follow-up, and dose-response characterization needed to support clinical translation.

AUG 8, 2026 · JOURNAL ARTICLE

Loss of Farnesoid X Receptor promotes colorectal liver metastasis via the GutFXR–FGF15–PPARγ–VEGFα–MDSC axis

Molecular Medicine

Preclinical mechanistic study in mouse models identifying a signaling axis and proposing a therapeutic target, without human efficacy data or clinical validation.